Parkinson’s Disease Therapeutics in Major Developed Markets to 2021: Early Pipeline Shifts Towards Disease-Modifying Therapies, while Short Term Growth Driven by Long-Acting Symptomatic Treatments

Parkinson’s Disease Therapeutics in Major Developed Markets to 2021: Early Pipeline Shifts Towards Disease-Modifying Therapies, while Short Term Growth Driven by Long-Acting Symptomatic Treatments is a professional and in-depth study. Summary

MRRS adds "Parkinson’s Disease Therapeutics in Major Developed Markets to 2021: Early Pipeline Shifts Towards Disease-Modifying Therapies, while Short Term Growth Driven by Long-Acting Symptomatic Treatments" latest studies, published in November 2016. It is a professional and in-depth study.

Summary
Parkinson’s Disease (PD) is a progressive, chronic neurodegenerative condition, which is currently incurable. It is associated with old age, and characterized by the loss of neurons in the substantia nigra region of the brain. The global Parkinson’s Disease (PD) prevalence was estimated at 16.1 million in 2011, and after Alzheimer’s disease it is the second most common neurodegenerative disease worldwide.

Parkinson’s Disease (PD) is a progressive disease and, although not fatal, it can develop severe symptoms and complications that significantly impact upon the patient’s quality of life. Symptoms for each stage can be categorized into early, moderate and advanced stages. Major motor symptoms of Parkinson’s Disease (PD) include tremors and difficulty walking. Parkinson’s Disease (PD) also gives rise to non-motor symptoms, such as dementia, depression, hallucinations and loss of taste and smell.

There are several different drug classes available to relieve Parkinson’s Disease (PD) symptoms. The aim is for treatments to increase dopamine levels, which is substantially diminished in brains affected by Parkinson’s Disease (PD). The most common therapies include levodopa, dopamine agonists and Monoamine Oxidase-B (MAO-B) inhibitors, with the choice of therapies dependent on patient symptoms and lifestyle. As the disease develops, the medication will need to be taken more strictly, due to the effect of drugs wearing off (known as off- time), which causes symptoms to return before the next dose.

Table of Contents
3 Marketed Products 25
3.1 Overview 25
3.1.1 Dopamine Replacement Therapies 25
3.1.2 MAO-B Inhibitors 28
3.1.3 Dopamine Agonists 30
3.1.4 COMT Inhibitors 35
3.1.5 Other Drugs Targeting Non-motor Symptoms of PD 39
3.2 Comparative Efficacy and Safety 40
4 Pipeline for Parkinson’s Disease 44
4.1 Overview 44
4.2 Pipeline Distribution by Mechanism of Action/Molecular Target 46
4.3 Clinical Trials 49
4.3.1 Failure Rate 49
4.3.2 Clinical Trial Duration 51
4.3.3 Clinical Trial Size 53
4.3.4 Comparison of Average Trial Metrics by Phase and Mechanism of Action 55
4.4 Promising Pipeline Molecules 56
4.4.1 Opicapone – Bial 56
4.4.2 Nuplazid (pimavanserin) – Acadia Pharmaceuticals 58
4.4.3 Nurelin (Amantadine Hydrochloride Extended-Release) – Adamas Pharmaceuticals 59
4.4.4 Tozadenant – Biotie Therapies 60
4.4.5 APL-130277 (apomorphine hydrochloride) – Cynapsus Therapeutics 61
4.4.6 P2B001 (pramipexole dihydrochloride + rasagiline mesylate) – Pharma Two B 63
4.4.7 DM-1992 (levodopa + carbidopa extended release) – Depomed 63
4.4.8 CVT-301 (levodopa) – Acorda Therapeutics 65
4.4.9 Dipraglurant Immediate-Release– Addex Therapeutics 65
4.4.10 Accordion Pill (levodopa and carbidopa) – Intec Pharma 66
4.4.11 ND-0612L (levodopa and carbidopa) – NeuroDerm 67
4.5 Heatmaps of Safety and Efficacy for Parkinson’s Disease Pipeline and Marketed Products 69
4.6 Pipeline Product Heat Map and Product Competitiveness Framework 73
5 Market Forecast to 2021 74......

List of Tables and Figures 
Table 1: Gene Mutations Related to Parkinson’s Disease and Corresponding Clinical Phenotypes 12
Table 2: Hoehn and Yahr Scale and the Definition of Disability Stages 16
Table 3: Unified Parkinson’s Disease Rating Scale 16
Table 4: All Pipeline Products by Phase, Discovery 96
Table 5: All Pipeline Products by Phase, Preclinical 100
Table 6: All Pipeline Products by Phase, IND/CTA-filed 112
Table 7: All Pipeline Products by Phase, Phase I 113
Table 8: All Pipeline Products by Phase, Phase II 115
Table 9: All Pipeline Products by Phase, Phase III 117
Table 10: All Pipeline Products by Phase, Phase III and Pre-registration 118
Table 11: Global, Parkinson's Disease Market Forecast, 2014–2021 118
Table 12: US, Parkinson's Disease Market Forecast, 2014–2021 118
Table 13: Canada, Parkinson's Disease Market Forecast, 2014–2021 119
Table 14: UK, Parkinson's Disease Market Forecast, 2014–2021 119
Table 15: France, Parkinson's Disease Market Forecast, 2014–2021 119
Table 16: Germany, Parkinson's Disease Market Forecast, 2014–2021 120
Table 17: Italy, Parkinson's Disease Market Forecast, 2014–2021 120
Table 18 : Spain, Parkinson's Disease Market Forecast, 2014–2021 120
Table 19: Japan, Parkinson's Disease Market Forecast, 2014–2021 121.....

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