Specificity and Quantification in Chimerism Analysis

Deliberate assortment of genetic markers is required, tailored product-design is mandatory Biotype Diagnostic offers a commercially available multiparameter analysis for specific chimerism analysis.

Dresden, Germany, June 26, 2012 -- Chimerism analysis is compulsory to examine the therapeutic success of stem cell transplantation and to estimate the potential risk to suffer a relapse. Through this analysis, relative ratio of donor - and recipient - derived stem cells is quantitatively displayed and explicitly reveals the status of transplant engraftment. For this reason a deliberate and specific choice of the applied diagnostics is essential. Biotype Diagnostic developed a commercially available multiparameter analysis for specific chimerism analysis. This molecular application was validated by monitoring chimerism status of more than 200 related donor-recipient-pairs; a unique feature of that assays. Hence, this application meets all diagnostic requirements for a sensitive and informative chimerism analysis.

In general the predictive value of a multiparameter analysis relies on the sensitivity and the specificity of deployed components. These components also account for robustness and thus reproducibility of generated results. Therefore, the minute choice and accurate combination of parameters utilised is of vital interest if a reliable diagnostic should be established. The idea to compensate weaknesses of single parameters by inserting multiple other parameters is likewise misleading then the consumption that redundancy amongst single parameters could account for improved analytical value. A sound application to monitor chimerism requires strong components that generate as little background as possible and allow a clear, unambiguous differentiation of donor - and recipient - derived stem cells. Establishing such a diagnostic multiparameter analysis therefore asks for extensive bio-medical know-how and long lasting empirical value. Moreover, specific validation on relevant clinical samples is mandatory in order to test for specificity and significance.

Since most multiparameter analyses, applied for chimerism monitoring, have not specifically been tested for this medical area, this accurate test-system will be of high interest for clinical experts. Biotype is filling the market niche that has last for a long time by providing an expert solution for reliable and effective chimerism testing.

Mentype® Chimera® addresses 12 highly polymorphic genetic sequences that show balanced distribution within the population and generate only nominal background signal.

Dr. Sophia Mersmann
Biotype Diagnostic GmbH
Moritzburger Weg 67
Dresden, Germany
+49 351 8838 432

Contact Details

Company Name: Biotype Diagnostic GmbH
Issued By: Dr. Sophia Mersmann
Phone: +49 351 8838 432
Address: Biotype Diagnostic GmbH Moritzburger Weg 67 Dresden, Germany
City: Germany
State: Dresden
Zip: Germany
Country: Germany
Website: Visit the website

Keywords : stem cells, bio-medical, chimerism analysis, donor, genetic markers,

by Dr. Sophia Mersmann (few years ago!)

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